bucket handle) (A positive McMurrays test on clinical exam indicates a significant meniscal tear. Next Generation Regenerative Medicine (NGRM) will treat subjects with degenerative meniscal changes in tears but no acute or large bucket handle tears.) Upon review of the MRI, NGRM will only treat subjects with no grade 2 or grade 3 ligamentous sprains. (A significant LCL and MCL laxity or tear would be determined on clinical exam if there is no endpoint on valgus or Varus stress physical exam. No significant Medial Collateral Ligament (MCL) or Lateral Collateral Ligament (LCL) tear or laxity.Only subjects that have a single symptomatic knee will be enrolled. X-rays that demonstrate OA with the Kellgren-Lawrence grading scale of 2, 3 or 4 in at least one compartment of the knee either or both knees.Individuals 18 to 80 years old that have knee Osteoarthritis.Body weight > 45 kg and Body Mass Index (BMI) between 18 and 40 kg/m2 (i.e., subjects with a BMI >40 and 60 and 90 and 60 and 60 ml/min.Healthy, non-smoking, males and females.The subject must be willing and able to provide written informed consent.Participants will be blinded as to whether they receive a BMA injection or a corticosteroid injection. All participants will undergo a procedure. A corticosteroid injection is currently the standard of care for osteoarthritis patients having knee pain. Participants will be randomized to study arms to receive a BMA injection to the intra-articular knee, subchondral knee, both intra-articular and subchondral knee, or to receive a corticosteroid injection to the knee. Therefore, techniques and practices have been developed to collect minimally manipulated bone marrow aspirate (BMA), that contains Bone Marrow Derived Mesenchymal Stem Cells (BMDMSCs) and other endogenous acellular components, from knee OA patients for autologous transplantation in the treatment of their knee OA. The patient experiences pain that worsens over time.Īlthough current surgical therapeutic procedures to cartilage repair are clinically useful, they cannot restore a normal articular surface, and in many cases, resulted in the growth of inferior quality fibrocartilage. This can result in bone rubbing on bone and produce painful bone spurs. As the cartilage wears away, it becomes frayed and rough, and the protective space between the bones decreases. It is a degenerative type of arthritis that occurs most often in patients, as the cartilage in the knee joint gradually wears away. Osteoarthritis (OA) is the most common form of arthritis in the knee that affects millions of adults throughout the world and is the leading cause of disability. Why Should I Register and Submit Results?.
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